dermaviduals® DMS
  MenuMenu publications >> ingredients imprint sitemap German
 

Nitrogen – a driving force

 

With a ratio of 78 per cent, nitrogen is the most important element in air. A multitude of its compounds can be found in skin care preparations.

 

About 78 per cent in volume or in other words the major part of our atmosphere is made up of the colourless and inodorous nitrogen (N). With its 0,03% share in the earth`s crust nitrogen rather is a rare element on our planet, though. In contrast to the oxygen, we inhale the diatomic gas (N2) as a component of the air but we also exhale it unmodified. Yet still a large part of our body consists of compounds of nitrogen with other elements. How this came about is a fascinating chapter in the history of the earth and the evolution of life.

Zero hour

Initially the atmosphere and surface of the earth consisted of gases and inorganic liquids and minerals that reciprocally interacted in chemical reactions and physical effects. The impact of radiation and electric discharge played a decisive role here since the inert nitrogen was thus activated to combine with other elements. Based on the random principle, the earliest amino acids could develop among other substances or in other words, molecules consisting of carbon, hydrogen, oxygen and nitrogen.

Autocatalysis

The newly formed molecules had also been chemically reacting among each other. The amino acids linked together to form peptides (amide family). A particular feature of the oligopeptides, consisting of a few amino acid modules, and still more of the polypeptides with their numerous amino acid subunits is to accelerate chemical reactions. In other words: peptide structures have catalytic effects. In the case of amino acid reactions into more and more complex peptides this process is called autocatalysis.

Hand in hand

The peptides were able to catalyse chemical reactions and to reduplicate. This gradually paved the way for the formation of the precursors of enzymes. The most successful among them produced substances that again could either be modified or degraded or further synthetized by other enzymes. They further coordinated in order to gradually work hand in hand, according to the mass action law. With progressing degree of organisation, specialised structures developed that could replicate themselves. They are considered to be the preliminary stages of life. Today our genes precisely are the organizational key for any and all the enzymes and their finely tuned activities formed later in our body.

Synergies

This is the reason why our organism depends on the intake of nitrogen-containing amino acids, peptides including specific proteins, and of vitamins. We are at the tail of the food chain that starts with the bacteria that live in the water, in the soil or in symbiosis with plants and that in the course of millions of years have learned to fixate the nitrogen of the air with the help of enzymes. And there is more to it: our organism could not work without the synergies with the microorganisms of the gastro-intestinal tract and the skin. They all work with the same tools, that is to say the essential nitrogen compounds.

Skin care

At the beginning of the 20th century, the chemical industry finally managed to catalytically sequester the atmospheric nitrogen and subsequently synthesize myriads of its compounds. And this is the reason why a multitude of these substances can be found in skin care products. There is no surprise, though, that these are the same substances that played a role in evolution.

Amino acids

Amino acids are the main components of the NMF (Natural Moisturizing Factor) and work as effective radical scavengers by intercepting nitrogen oxide radicals of the air, among others, and transforming them into harmless atmospheric nitrogen. A sound NMF is a basic requirement for the osmotic balance and a smoothly working skin barrier.
Ectoin is a water-binding cyclic amino acid and occurs in bacteria that also can live in saline lakes under high osmotic pressure. Ectoin improves the irritation threshold of the skin and is used, frequently in liposomal form, in preparations applied for sensitive skin.

Amides

With their hydrogen bridge bonds amides adhere well to the skin surface. Certain amides such as the ceramides even have barrier-active effects. It involves an anti-itching effect which however is more pronounced with urea, allantoin and fatty acid alkanolamides such as palmitic acid ethanolamide. High concentrations of urea have a keratolytic effect and enhance the penetration of other substances.
Ceramides impede the dehydration of the skin and the penetration of foreign substances. They are usually applied in the case of dry skin and in the context of skin protection. In the hair care, ceramides are integrated into the interspaces between hairs.
The amides capsaicin (chili) and spilanthol (paracress) belong to the pungent substances. They have local anaesthetic effects and so reduce the muscle contraction of the facial lines which leads to an effective smoothing of wrinkles. Hyaluronic acids are related to the polysaccharides and have a high water retaining capacity as well as a skin smoothing effect.

Peptides

Various short-chained peptides are used as collagen boosters (matrikins) and botox-like wrinkle-smoothing tools. Enzyme peelings cleave the peptides and proteins and stimulate the skin renewal. Collagen- and wheat protein hydrolysates and their condensates smooth the skin similar to hyaluronic acid by forming hydrogen bridges to the keratin. Growth factors are natural peptides of the body that can be stimulated with the administration of vitamin A.

Vitamines

Vitamin B1 (thiamin), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid) and vitamin B12 (cyanocobalamin) without exception contain nitrogen atoms in the form of amines and amides. Provitamin B5 (D-panthenol) has anti-inflammatory and penetration-enhancing effects; the latter-mentioned is used in facial tonics and above all in mask treatment products.

Further nitrogen compounds (a selection)

  • Dimethylaminoethanol (DMAE) is ascribed to have wrinkle-reducing and moisturizing effects. The substance occurs as a metabolite of the phosphatidylcholine-bound choline, among others.
  • Phosphatidylcholine (PC) is a phospholipid with a many-faceted spectrum of activity and, besides the sphingomyelins and ceramides, belongs to the essential membrane-forming natural substances.
  • The alkaloids are a heterogenic nitrogen-containing substance group which, besides nicotine and morphine, also comprises caffeine (also used in cosmetic applications) and the anti-inflammatory berberine.
  • Nitrogen monoxide (NO) and nitrogen dioxide (NO2) develop after electric discharges and in the context of combustion processes. In the body nitrogen monoxide is released in controlled conditions as a neurotransmitter. Nitrous oxide (alias laughing gas – N2O) also is a nitric oxide however not a radical. It has anaesthetic effects. Nitrosamines are the reaction product of secondary amines with nitrogen oxides. They are considered to be cancer-triggering substances.


Dr Hans Lautenschläger

 
Please note: The publication is based on the state of the art at the publishing date of the specialist journal.

Please use the reader-view for mobile terminals.
If there are any questions, do not hesitate to contact us via koko@dermaviduals.de .
This applies to any misprint or other relevant mistakes on this page too.
© Copyright Kosmetik Konzept KOKO GmbH & Co. KG, Leichlingen, www.dermaviduals.de
Revision: 01.08.2021
 
  pdf
Download
 

published in
Beauty Forum medical
2021 (2), 22-23

 
ingredients - further literature
Sulphur for a beautiful skin
Water – more than just wet
Nitrogen – a driving force
Oxygen – a premier class element
Oxygen – more than just hot air
Thermal springs – an overview on thermal waters
Small but mean – plastics and microplastics in cosmetic products
The pH value of the skin and of cosmetic preparations
CO2 – more than just a greenhouse gas
Complexing agents & Co - ambivalent ingredients in cosmetic products
Aluminium Update
Natural resources - herbal oils in skin care
Hidden harmful substances in cosmetic products
Endocrine disruptors - harmful for the endocrine system
Glycols in skin care preparations and dermatics
Sterile packaging - products and methods
Triclosan - partial ban, widely used
Aluminium - a much-discussed element1
Waxes - an indispensable family
Summary: Release and bioavailability
Piggyback - an overview on transport systems
Without carriers only modest effects - Functions and effects of carriers in cosmetic products
Silicon - the global player in cosmetics
On substances that release emotions - a tour across the world of perfumes
From soap to high-tech emulsifiers
Acids and bases from A to Z
Ubiquitous like sand on the beaches: silicon and its compounds
Fragrance sample? Aldehydes and ketones
Versatile use - alcohols in skin care products
Denatured!!? - Use pure alcohol!
Denaturants in cosmetic products - health is secondary
(Poly)Saccharides in cosmetic products - From alginate to xanthan gum
Polyethylene glycols & Co - On effects and side effects
Vegetable oils
Shelf life of cosmetics - what makes cosmetic products unstable?
Vegetable oils and extracts - essential components
Quite a lot of different applications - new oils and extracts
A closer look on natural agents: facts and future aspects
Water and water - just not the same things: water qualities
Preservatives
Lipophilic substances - oils and lipids in cosmetic products
Shelf life and preservation
Emulsifiers enable mixtures
Ingredients - objective information appreciated
Preservatives - germs et al. under control
Additives in cosmetic products
Active agents - the effective skin care: lipids, the basic elements
Active agents, the effective skin care - vitamins, oils & more
Active agents, the effective skin care - smoothing the skin and providing overall protection
INCI - Declaration
Free from preservatives
Emulsions - micro-emulsions - nano-emulsions
Emulsifiers - looking for alternatives
Ceramides - lipids with multiple assignments