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Is there a difference between unilamellar and multilamellar liposomes?


Cosmetic liposomes always consist of a mixture of unilamellar and multilamellar liposomes as the manufacturing process for pure unilamellar liposomes is much more elaborate and hence more expensive. 

In contrast to differing advertising messages, the number of shells has no influence on the encapsulation, penetration and efficacy of active agents. The concentration of phosphatidylcholine (PC) is the crucial factor in the efficacy of liposomes.

The penetrating mechanism is described in the publication "Applied corneotherapy and skin care - guidelines for the anti-aging treatment" 

Dr. Hans Lautenschläger

Please note: The contribution is based on the state of the art at the revision date.

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Revision: 27.05.2021